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Parameters of Necrotizing Entero Colitis Include Histopathology, Diagnosis, Differential Diagnosis, Treatment

Muralinath E., Prapurnachandra Y., Ramesh Y., Pravithra V., Lalitha Ch., Babyshalini Ch., Venkatesh B., Guruprasad M.

Abstract


Necrotizing enterocolitis (NEC) is a potentially fatal disease that nearly exclusively affects newborns and has a 50% death rate. The pathophysiology of NEC is intestinal inflammation that leads to bacterial invasion, which causes cellular damage, death, and necrosis in both the colon and the intestine. As NEC progresses, intestinal perforation can cause sepsis and even death. Poor feeding, vomiting, lethargy, and abdominal discomfort are some of the non-specific signs and symptoms of NEC. This exercise highlights the importance of an interdisciplinary team approach to the care of affected individuals and provides information on the presentation, assessment, and treatment of necrotizing enterocolitis.


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Afzal, B., Elberson, V., McLaughlin, C., & Kumar, V. H. (2017). Early onset necrotizing enterocolitis (NEC) in premature twins. Journal of Neonatal-Perinatal Medicine, 10(1), 109–112. https://doi.org/10.3233/NPM-16137

Bron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017). Can probiotics modulate human disease by impacting intestinal barrier function? British Journal of Nutrition, 117(1), 93–107. https://doi.org/10.1017/S0007114516004037

Craven, D. P., Fowler, J. S., & Foster, M. E. (1999). Management of a neonate with necrotizing enterocolitis and eight prolapsed stomas in a dehisced wound. Journal of Wound, Ostomy and Continence Nursing, 26(4), 214–220.

Cruchet, S., Furnes, R., Maruy, A., Hebel, E., Palacios, J., Medina, F., Ramirez, N., Orsi, M., Rondon, L., Sdepanian, V., Xóchihua, L., Ybarra, M., & Zablah, R. A. (2015). The use of probiotics in pediatric gastroenterology: A review of the literature and recommendations by Latin-American experts. Paediatric Drugs, 17(3), 199–216. https://doi.org/10.1007/s40272-015-0124-6

Cuna, A., George, L., & Sampath, V. (2018). Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions. Seminars in Fetal and Neonatal Medicine, 23(6), 387–393. https://doi.org/10.1016/j.siny.2018.08.006

Dylag, K., Hubalewska-Mazgaj, M., Surmiak, M., Szmyd, J., & Brzozowski, T. (2014). Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders. Current Pharmaceutical Design, 20(7), 1149–1155.

Fagenholz, P. J., & de Moya, M. A. (2014). Acute inflammatory surgical disease. Surgical Clinics of North America, 94(1), 1–30. https://doi.org/10.1016/j.suc.2013.10.005

Geng, Q., Wang, Y., Li, L., & Guo, C. (2018). Early postoperative outcomes of surgery for intestinal perforation in NEC based on intestinal location of disease. Medicine, 97(39), e12234. https://doi.org/10.1097/MD.0000000000012234

Gephart, S. M., Hanson, C., Wetzel, C. M., Fleiner, M., Umberger, E., Martin, L., Rao, S., Agrawal, A., Marin, T., Kirmani, K., Quinn, M., Quinn, J., Dudding, K. M., Clay, T., Sauberan, J., Eskenazi, Y., Porter, C., Msowoya, A. L., Wyles, C., Avenado-Ruiz, M., Vo, S., Reber, K. M., & Duchon, J. (2017). NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis. Maternal Health, Neonatology and Perinatology, 3, Article 23. https://doi.org/10.1186/s40748-017-0062-0

Rugolotto, S., Gruber, M., Solano, P. D., Chini, L., Gobbo, S., & Pecori, S. (2007). Necrotizing enterocolitis in a 850 gram infant receiving sorbitol-free sodium polystyrene sulfonate (Kayexalate): Clinical and histopathologic findings. Journal of Perinatal Medicine, 27(4), 247–249. https://doi.org/10.1038/sj.jp.7211675

Versalovic, J. (2013). The human microbiome and probiotics: Implications for pediatrics. Annals of Nutrition and Metabolism, 63(Suppl. 2), 42–52. https://doi.org/10.1159/000354899

Wilkins, T., & Sequoia, J. (2017). Probiotics for gastrointestinal conditions: A summary of the evidence. American Family Physician, 96(3), 170–178.


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