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Effects of coconut water and bitter leaf on Triglycerides and Cholesterol in Cyclosporine- induced Wistar Rats

Okike P. I., Edebiri O. E., Blackie O. H., Alwell R., Omende K., Oviangbede G. E., Nze P. O.

Abstract


This study investigates the effects of aqueous extracts of Vernonia amygdalina and coconut water on Triglyceride and Cholesterol  of cyclosporine-induced Wistar rats. By examining their impact on  cholesterol and triglycerides, this research seeks to provide evidence for their potential therapeutic applications. Sixteen(16) Cyclosporine-induced cholesterol Albino wistar rats were divided into four (4) groups (Group A-D) consisting of four (4) rats in each group, which were tagged and housed in separate cages Group A served as the negative control group and will be administered sterile water and standard feed throughout the experiment. Group B served as the experimental group and will be administered 10mg/kg cyclosporine for the experiment. Group C served as the experimental group which is induced with 200mg/kg cyclosporine for hypercholesterol and will be administered 5ml/kg of the extract for the experiment. Group D served as the experimental group which is induced with 400mg/kg cyclosporine for hypercholesterol and were   administered 10ml/kg of the extract for the experiment. Blood samples were collected between the hours of 8 and 11 in the morning on the same day.  Triglyceride and Cholesterol, were all analyzed with the help of Blood Lipid Panel test. Data obtained was expressed as mean ± standard error of mean and statistically evaluated using one-way analysis of variance (ANOVA) followed by Statistical Package for the social sciences(SPSS) (International Business Machines (IBM), United States) Statistics v.23 package was used to analyze the results with p<0.05 considered significantly. This present study  revealed a significant hypolipidemic effect of  aqueous extract of Vernonia amygdalina and Buko juice of cyclosporine-induced dyslipidemia in Wistar rats , as indicated by the reductions in cholesterol  and triglyceride  levels.


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