Open Access Open Access  Restricted Access Subscription Access

Exploring the Impact of Drugs on Decerebrate Rigidity

Dr. Muralinath. E, Sony Sharlet E, Mohan Naidu K., Srinivas Prasad Ch, Jayinder Paul Singh G, Pradip Kumar Das, Panjan Ghosh. P, Kinsuk Das S., Kalyan C, Archana Jain, Guruprasad M

Abstract


Decerebrate rigidity happens because of the damage to the brain stem, disrupting the normal inhibitory pathways that regulate muscle tone .Decerebrate rigidity is a state of disputed signals between the brain and the Spinal cord particularly involving the reticular formation in the brain stem. A very few drugs can target various transmitter systems participated in motor control such as GABA, glutamate , dopamine and serotonin. Levo dopa or dopamine agonists have been investigating d for their potential to improve motor symptoms associated with decerebrate rigidity. NMDA receptor antagonists like keyamibe or memantine have been studies for their potential to reduce spasticity and muscle rigidity. Drugs that enhance sertonergic activity such as selective serotonin reuptake inhibitor ( SSTRIs) have been explored for their potential effects on muscle rigidity. Finally, it is concluded that Decerebrate rigidity poses significant challenges for individuals influence by neurological disorders or injuries.


Full Text:

PDF

References


Davis RA, Davis L. Decerebrate rigidity in humans. Neurosurgery. 1982 May;10(5):635-42.

Al-Chalabi M, Reddy V, Gupta S. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Aug 14, 2023. Neuroanatomy, Spinothalamic Tract

Welniarz Q, Dusart I, Roze E. The corticospinal tract: Evolution, development, and human disorders. Dev Neurobiol. 2017 Jul;77(7):810-829.

McCall AA, Miller DM, Yates BJ. Descending Influences on Vestibulospinal and Vestibulosympathetic Reflexes. Front Neurol. 2017;8:112.

Yang HS, Kwon HG, Hong JH, Hong CP, Jang SH. The rubrospinal tract in the human brain: diffusion tensor imaging study. Neurosci Lett. 2011 Oct 17;504(1):45-8.

Barkovich AJ, Millen KJ, Dobyns WB. A developmental and genetic classification for midbrain-hindbrain malformations. Brain. 2009 Dec;132(Pt 12):3199-230.

Yagmurlu K, Rhoton AL, Tanriover N, Bennett JA. Three-dimensional microsurgical anatomy and the safe entry zones of the brainstem. Neurosurgery. 2014 Dec;10 Suppl 4:602-19; discussion 619-20.

Ruchalski K, Hathout GM. A medley of midbrain maladies: a brief review of midbrain anatomy and syndromology for radiologists. Radiol Res Pract. 2012;2012:258524.

Moon JW, Hyun DK. Decompressive Craniectomy in Traumatic Brain Injury: A Review Article. Korean J Neurotrauma. 2017 Apr;13(1):1-8.

Woischneck D, Skalej M, Firsching R, Kapapa T. Decerebrate posturing following traumatic brain injury: MRI findings and their diagnostic value. Clin Radiol. 2015 Mar;70(3):278-85.


Refbacks

  • There are currently no refbacks.