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The Effect of Potash on the Histology of the Kidney and Full Blood Count of Rabbit

Okike P.I., Edebiri O.E., Okeh P.O., Okoronkwo C.A., Omende K., Orunta E.D., Okekpa U.O.

Abstract


The aim of this study is to determined the effects of potash on the histology of the kidney and full blood count of rabbit. Sixteen (16) rabbits (weighing 850g – 900g) were used for this study. The animals were randomly assigned into four groups with four rabbits in each group. Group A served as control, while B, C, and D served as the test groups. Group A (control): 4 rabbits (control) were fed with growers mash 100g/850g body weight without administering potash. Group B: 4 rabbits were fed with 100g of growers mash mixed with 5g of ground potash/850g body weight. The feeding was performed once daily for 7 days. Group C: 4 rabbits were fed 100g of growers mash mixed with 5g of ground potash/850g body weight. The feeding was performed once daily for 14 days. Group D: 4 rabbits were fed 100g of growers mash mixed with 5g of ground potash/850g body weight. The feeding was performed once daily for 21 days. Before the sacrifices, blood samples were collected via the eyes of the rabbits using 2ml syringe, and the blood were transferred into EDTA container. After exposure, all the rabbits in group A (control) and group B, C, and D (test) were sacrificed and the kidney harvested for histological examination. Data obtained   were analysed using Statistical Package for Social Sciences (SPSS) version 21. One-way Analysis of Variance (ANOVA; 95% confidence interval) was used to determine the significance of difference in the mean of all parameters and the result presented as Mean ± Standard error of mean (SEM). The results were considered statistically significant at p ≤ 0.05 level of significance. The results obtained from this study that administration of potash has detrimental effects on the kidney and blood parameters of rabbits. These effects were seen to be in a time-dependent manner.


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References


Ajao, A. A., Ojo, M. O., Oladipo, O. T., Yusuf, A. A., & Mukaila, Y. O. (2018). Clerodendrum volubile P. Beauv (Lamiaceae), an underutilized indigenous vegetable of utmost nutritive and pharmacological importance. Beni-Suef University Journal, 7(2), 606-611.

Ajiboye, H. O., Raji, A. O., Adeleye, N. S., Adigun, O. B., Giwa, O. B., Ojewuyi, A. T., & Oladiji, A. T. (2016). Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats. Journal of the Science of Food and Agriculture, 96(5), 1522-1531.

Bamishaiye, E. I., Muhammad, N. O., & Bamishaiye, O. M. (2009). Hematological parameters of albino rats fed on tiger nuts (Cyperus esculentus) tuber oil meal-based diet. The International Journal of Nutrition and Wellness, 10, 1-5

Bankole, J. K., Ngokere, A. A., Ajibade, O. M., Igunbor, C. M., & Eloka, C. C. V. (2015). Degenerating effects of potash (KaunK2CO3) on the kidney: Unabated continental challenge to human health in Nigeria. Annals of Biology Research, 6(3), 12-18.

Ekpa, O., Palacios-Rojas, N., Kruseman, G., Fogliano, V., & Linnemann, A. R. (2019). Sub-Saharan African maize-based foods - Processing practices, challenges and opportunities. Food Reviews International, 35(7), 609-639.

Ellison, D. L., & Farrar, F. C. (2018). Kidney influence on fluid and electrolyte balance. The Nursing Clinics of North America, 53(4), 469-480.

Helga BI, Ojo N, Attah MO. (2017). Effect of Sodium Carbonate (Potash) On the Birth Weight of Albino Rat Pups. Nova Journal of Medical and Biological Sciences, 6(2), 1-7.

Hoenig, M. P., & Zeidel, M. L. (2014). Homeostasis, the milieu intérieur, and the wisdom of the nephron. Clinical Journal of the American Society of Nephrology: CJASN, 9(7), 1272-1281. https://doi.org/10.2215/CJN.08860813.

Srivastava, A., Palsson, R., Kaze, A. D., Chen, M. E., Palacios, P., Sabbisetti, V., Betensky, R. A., Steinman, T. I., Thadhani, R. I., McMahon, G. M., Stillman, I. E., Rennke, H. G., & Waikar, S. S. (2018). The prognostic value of histopathologic lesions in native kidney biopsy specimens: Results from the Boston Kidney Biopsy Cohort Study. Journal of the American Society of Nephrology: JASN, 29(8), 2213-2224.


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