Calculation of the Left Ventricular Myocardial Infarction Prognosis

Abstract

Heart Failure (HF) due to Acute Myocardial Infarction (AMI) is a common heart condition with significant short-term and long-term mortality risks. AMI leads to a progressively impaired interaction between the left ventricle (LV) and systemic arteries, with compromised LV contractility and stiffness. The reduction in global transverse and longitudinal strain is indicative of this dysfunction. Factors such as reduced ejection fraction (EF), changes in LV geometry, infarct zone (IZ) size and location, and myocardial properties like stiffness and contractility further contribute to this condition. To address these challenges, we employed a mathematical finite element model of the LV to analyze the impact of AMI characteristics on systolic function. Simulations were performed to evaluate how changes in LV shape and myocardial stiffness affect cardiomyocyte strain. Our results suggest that increased myocardial stiffness can mimic the systolic blood pressures, EF, and strain values observed in AMI patients, indicating that myocardial stiffness is elevated in HF AMI patients.