Journal of Advances in Pharmaceutical Sciences
This is blind peer-reviewed journal that provides a platform which aspires to cover all the aspects of Pharmaceutical Sciences. Focus and Scope Pharmaceutics Pharmacology Pharmaceutical Analysis Pharmacognosy Pharmaceutical Chemistry Cardiovascular Pharmacology Cancer Pharmacogenomics Dental Pharmacology Pharmaceutical Nanotechnology Pharmaceutical Science Pharmaceutical Technology Pharmaceutical Toxicology and Metabolic Inhibitors
Understanding Nail Polish Removers: Chemical Principles, Performance, and Safety Assessment
Nail polish removers serve as cosmetic products which remove nail polish while protecting the nails from damage. These products use organic solvents as their main ingredient with acetone being the most common choice because it dissolves substances quickly and customers can easily wash it off with water. The human body develops harmful effects from acetone when people use it too often because it causes their nails to lose moisture and become weak while their skin develops irritation and the area around their nails turns red. The cosmetic industry uses ethyl acetate and isopropyl alcohol as solvent alternatives which provide a less powerful but more expensive method for nail polish removal. Nail polish removers operate by breaking down film-forming polymers which include nitrocellulose to enable nail lacquer dissolution and easy removal via wiping. Modern formulas reduce solvent damage by employing conditioning agents which contain glycerin and natural oils and vitamins to maintain moisture levels while they safeguard the nail surface. The advancements made in these products still face major challenges because people in work environments face dangers through toxic substances and inhalation exposure and long-term product usage. Researchers now study methods to create safer and environmentally friendly products which include bio-based solvents and systems derived from plants and new product designs like gels and wipes. The environmental impact of VOC emissions and improper waste disposal practices demonstrates the necessity for biodegradable and environmentally sustainable solutions which should guide development of future product formulas.
Analytical Method Development and Validation of Eleutherosides Using HPTLC Technique
For both qualitative and quantitative investigation of pharmaceutical and herbal chemicals, High-Performance Thin-Layer Chromatography (HPTLC) is a flexible and trustworthy analytical method. The invention and validation of a straightforward, reliable, and accurate HPTLC method for the measurement of eleutherosides in herbal formulations is the main goal of the current study. Ether, ethyl acetate, and ortho-phosphoric acid (6:3.5:0.5 v/v) were used as the mobile phase and silica gel 60 F254 aluminum plates as the stationary phase to accomplish chromatographic separation. At 220 nm, densitometric analysis was performed. With a correlation coefficient of 0.9991, the method showed good breadth in the concentration range of 500–3000 ng/spot. In accordance with ICH recommendations, validation criteria such as accuracy, precision, repeatability, robustness, and sensitivity were assessed. The results showed that the limits of quantitation (LOQ) and detection (LOD) were 706.14 ng and 233.02 ng, respectively. Eleutherosides in herbal formulations were effectively analyzed using the devised approach, which demonstrated its dependability, sensitivity, and suitability for regular quality control analysis.
Monkeypox Virus: Current Insights into Transmission, Diagnosis, and Therapeutic Strategies
Monkeypox virus (MPXV) is the causative agent of monkeypox, a zoonotic illness. MPXV is endemic in West and Central Africa's forested regions, but the virus is currently spreading globally, resulting in breakouts in several non-endemic nations. The human monkeypox virus (MPVX) was first detected in 1958. Since then, the disease has spread sporadically. Endemic regions have been noticed throughout central and western Africa. The World Health Organization designated the epidemic a public health emergency of international significance due to the Mpox virus's rapid spread. In recent years, monkeypox cases have increased in places where the illness is not endemic. Notably, in 2022, India reported its first confirmed case of monkeypox. As a result, governments increased their efforts to investigate therapeutic options aimed at controlling the sickness and its spread. Nevertheless, the treatment choices for Mpox virus infection are limited.
Advancing Therapeutics through Smart Polymeric Complex Systems
Polyelectrolyte complexation has gained significant attention as an effective and versatile approach in the development of advanced pharmaceutical and biomedical systems. Formed through electrostatic interactions between oppositely charged polymers, these complexes offer unique physicochemical properties that support diverse therapeutic applications. The formation and stability of such systems are influenced by various factors, including pH, ionic strength, polymer concentration, molecular weight, and charge ratio. Based on their structural and functional characteristics, polyelectrolyte complexes can be classified into different types for specific biomedical purposes. Their mechanism of formation enables efficient drug encapsulation, sustained release, targeted delivery, and improved therapeutic efficacy. In addition to drug delivery, their applications extend to gene delivery, tissue engineering, wound healing, and vaccine formulations. Owing to advantages such as biocompatibility, biodegradability, and ease of preparation, polyelectrolyte complexation represents a promising strategy for designing innovative and efficient therapeutic systems.
Exploring Emulgel as a Modern Approach to Topical Drug Delivery: A Comprehensive Review
Topical drug delivery systems are widely utilized for administering therapeutic agents through the skin and other accessible body sites such as the vagina, eyes, and throat, offering both local and systemic effects. Among the emerging approaches, emulgel has gained significant attention as a novel and effective drug delivery system. Emulgel combines the advantages of both emulsions and gels, making it particularly suitable for the incorporation of hydrophobic drugs. It is typically formulated by integrating an oil-in-water (O/W) or water-in-oil (W/O) emulsion into a gel base using appropriate gelling agents. The presence of surfactants and co-surfactants reduces interfacial tension, enhancing drug solubilization and stability. Emulgel exhibit desirable properties such as improved drug permeability, controlled release, better patient compliance, and ease of application. Additionally, their thermodynamic stability and ability to enhance bioavailability make them a promising alternative to conventional topical formulations. This review highlights the formulation strategies, mechanism, advantages, and therapeutic applications of emulgel systems in modern drug delivery.