Statin Induced Cholesterol Lowering Effect on Prolonged Castration Inhibition (Castration-Resistance Delay) May Navigate the Prostate Cancer Spread or Progress after Androgen Deprivation Therapy: Randomized double-blind phase 3 clinical study protocol for

Abstract

Cardioprotective statins keep cholesterol low in the blood.  High blood cholesterol raises the risk of recurrent prostate cancer in patients with post-prostatectomy survivors with cardiac disease.  The statins perform mainly two functions:  1. Statins prolong the time period to begin castration resistance during androgen deprivation therapy for prostate cancer;  2. Statins may biosense or navigate the prostate cancer spread as the predictor of the enhanced patient outcome.  The present study protocol will test the statin action on delaying castration-resistance in a randomized placebo-controlled manner.